Exosome depleted Fetal Bovine Serum like the name suggests utilizes majority of the endogenous exosomes from the cell culture, around 90% of the exosomes are used up. In fact, before every testing, every sample is tested for the exosome depletion.
It helps scientists with research purposes with regards to diseases like Parkinson’s disease, cardiovascular disease and other infectious diseases. Also, it is the only Fetal Bovine Serum which consumes majority of exosomes from cell culture without reducing other growth enhancing nutrients.
This procedure is done in diagnostic laboratories for accurate results. Exosome depletion is done using a method called centrifugation.
Culture media is prepared for biochemical testing.
You can order it online here.
The good suggested protocol for exosome depletion is that the FBS need to be centrifuged for at least 18 hours at 100,000xg. In fact, there some scientists or investigators who would even suggest centrifugation for just about one and half hours only. But then it is a suggestion of the minority.
This serum is developed to reduce exosomes in a gentle manner.