Product Name Anti-Cathepsin L Antibody (Monoclonal, 33/2)Description Mouse IgG monoclonal antibody for Cathepsin L, cathepsin L1 (CTSL1)detection. Tested with WB, IHC-F in Human;mouse;rat. No cross reactivitywith other proteins.Host MouseTarget Species Human, Mouse, RatApplication IHC-F, WBRecommended Detection SystemsWe recommend Enhanced Chemiluminescent Kit with anti-Mouse IgG(EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG SuperVision Assay Kit (SV0001-1) for IHC(F).Immunogen Procathepsin L isolated from the human lung cancer cell line EPLC 32M1.Specificity No cross reactivity with other proteinsPack Size 100μg/vialCatalog # Ab1014Background for Cathepsin L1Cathepsin L is a lysosomal cysteine proteinase with a major role in intracellular protein catabolism. It alsoshows the most potent collagenolytic and elastinolytic activity in vitro of any of the cathepsins. CathepsinL has been implicated in pathologic processes including myofibril necrosis in myopathies and inmyocardial ischemia, and in the renal tubular response to proteinuria. Human liver cathepsin L consists ofa heavy chain of about 25 kD and a light chain of about 5 kD. The gene is mapped to 9q21-q22.Cathepsin L is required for endothelial progenitor cell-induced neovascularization.