Anti-Caldesmon (Smooth) Antibody (Monoclonal,hHCD)

Description

Product Name Anti-Caldesmon (Smooth) Antibody (Monoclonal, hHCD)
Description Mouse IgG monoclonal antibody for Caldesmon (smooth),
caldesmon 1 (CALD1) detection. Tested with WB, IHC-P in
Human;mouse;rabbit. No cross reactivity with other proteins.
Host Mouse
Target Species Human, Mouse, Rabbit
Application IHC-F, WB
Recommended Detection Systems: We recommends Enhanced Chemiluminescent Kit with anti-Mouse
IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse
IgG Super Vision Assay Kit (SV0001-1) for IHC(F).
*Blocking peptide can be purchased. Contact us for more information
Immunogen Human uterus smooth muscle extract.
Specificity No cross reactivity with other proteins
Pack Size 100μg/vial
Catalog Number Ab1009

Background:
Caldesmon is a potential actomyosin regulatory protein found in smooth muscle and
nonmuscle cells. The predicted smooth-muscle polypeptide is 793 amino acids long.
The high molecular weight caldesmon(h-CaD) is predominantly expressed in smooth
muscles, whereas the low molecular weight caldesmon(l-CaD) is widely distributed in
nonmuscle tissues and cells. Hayashi et al.(1992) demonstrated that the human CDM
gene is composed of 14 exons.

Gene Name CALD1
Protein Name Caldesmon
Gene Full Name caldesmon 1
Protein Function Actin- and myosin-binding protein implicated in the regulation of
actomyosin interactions in smooth muscle and nonmuscle cells
(could act as a bridge between myosin and actin filaments).
Stimulates actin binding of tropomyosin which increases the
stabilization of actin filament structure. In muscle tissues,
inhibits the actomyosin ATPase by binding to F-actin. This
inhibition is attenuated by calcium-calmodulin and is potentiated
by tropomyosin. Interacts with actin, myosin, two molecules of
tropomyosin and with calmodulin. Also play an essential role
during cellular mitosis and receptor capping. Involved in
Schwann cell migration during peripheral nerve regeneration
(By similarity).
Tissue Specificity High-molecular-weight caldesmon (isoform 1) is predominantly
expressed in smooth muscles, whereas low-molecular- weight
caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in
non-muscle tissues and cells. Not expressed in skeletal muscle
or heart.
Subcellular
Localization
Cytoplasm, cytoskeleton . Cytoplasm, myofibril . Note: On thin
filaments in smooth muscle and on stress fibers in fibroblasts
(nonmuscle).
Uniprot ID Human(Q05682), Mouse(Q8VCQ8), Rat(Q62736)
Alternative Names Caldesmon|CALD1

International:

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