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Product Name Anti-Calcineurin Alpha Antibody (Monoclonal, CN-A1)Description Mouse IgG monoclonal antibody for Calcineurin alpha, proteinphosphatase 3, regulatory subunit B, alpha (PPP3R1) detection.Tested with WB, IHC-P in Human;bovine;rat. No cross reactivitywith other proteins.Host MouseTarget Species Bovine, Human, Mouse, RatApplication IHC-P, WBRecommendedDetectionSystemsWe recommends Enhanced Chemiluminescent Kit with anti-MouseIgG (EK1001) for Western blot, and HRP Conjugated anti-MouseIgG Super Vision Assay Kit (SV0001-1) for IHC(F). *Blockingpeptide can be purchased. Contact us for more informationImmunogen Bovine brain calcineurin.Specificity No cross reactivity with other proteinsPack Size 100μg/vialCatalogNumberAb1008Background:Calcineurin, the Ca(2+)/calmodulin-regulated protein phosphatase, first detected inskeletal muscle and brain, has been found in all cells from yeast to mammals.Calcineurin A alpha(PPP3CA),is located on human chromosomes 4, Chromosomalmapping of the human genes for the calmodulin-dependent proteinphosphatase(calcineurin) catalytic subunit. Calcineurin regulates bone formation by theosteoblast.
Product Properties:Clonality MonoclonalClone Number CN-A1Form LyophilizedContents Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mgNaN3 as preservative. *carrier free antibody available upon request.Reconstitution Add 1ml of 1XPBS buffer (catalog # 1XPBS-001) will yield aconcentration of 100ug/ml.Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. Itcan also be aliquoted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.Purification AscitesApplication Details:Application Concentration*TestedSpeciesPredictedSpeciesAntigenRetrievalWestern blot 0.25-0.5μg/ml Human,bovine,mouse,rat–Immunohistochemistry(Paraffin-embedded Section)l 0.5-1μg/ml Human,bovine,mouse,rat– By Heat
Protein Target:Gene Name PPP3R1Protein Name Calcineurin subunit B type 1Gene Full Name protein phosphatase 3, regulatory subunit B, alphaProtein Function Regulatory subunit of calcineurin, a calcium-dependent,calmodulin stimulated protein phosphatase. Confers calciumsensitivity.SequenceSimilaritiesBelongs to the calcineurin regulatory subunit family.SubcellularLocalizationCytoplasm, cytosol . Cell membrane . Cell membrane,sarcolemma. Note: Translocates from the cytosol to thesarcolemma in a CIB1- dependent manner duringcardiomyocytes hypertrophy.Uniprot ID Human(P63098), Mouse(Q63810), Rat(P63100)Alternative Names Calcineurin subunit B type 1|Calcineurinalpha|PPP3R1|CalcineurinsubunitBtype1|Calcineurinalpha
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