Product Name Anti-BIN1 antibody (monoclonal)
Description Mouse IgG monoclonal antibody for BIN1, bridging integrator 1
(BIN1) detection. Tested with WB, IHC-F, ICC in Human; mouse
rat. No cross reactivity with other proteins.
Target Species Human, Mouse, Rat
Application WB,HC-P, IHC-F, ICC,
We recommends Enhanced Chemiluminescent Kit with anti-Mouse
IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse
IgG Super Vision Assay Kit (SV0001-1) for IHC(P), IHC(F) and
*Blocking peptide can be purchased. Contact us for more
Immunogen Recombinant polypeptide containing amino acids 189-398 of
Specificity No cross reactivity with other proteins
Pack Size 100μg/vial
Catalog Number Ab1005
BIN1(AMPH2) is a novel human gene product with features of a tumor suppressor
protein. BIN1 gene to chromosome 2q14. Loss of BIN1 expression appears to be a
frequent aberration in human hepatocellular carcinomas . mutations in BIN1 cause
centronuclear myopathy by interfering with remodeling of T tubules and/or endocytic
membranes, and that the functional interaction between BIN1 and DNM2 is necessary
for normal muscle function and positioning of nuclei.
Clone Number 99D
Contents Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg
NaN3 as preservative.
*carrier free antibody available upon request.
Reconstitution Add 1ml of 1XPBS buffer (catalog # 1XPBS-001) will yield a
concentration of 100ug/ml.
Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. It
can also be aliquoted and stored frozen at -20˚C for a longer time.
Avoid repeated freezing and thawing.
Application Concentration* Tested
Western blot 0.25μg/ml Human,
Immunocytochemistry 1μg/ml Human,
Gene Name BIN1
Protein Name Myc box-dependent-interacting protein 1
Gene Full Name bridging integrator 1
Protein Function May be involved in regulation of synaptic vesicle endocytosis.
May act as a tumor suppressor and inhibits malignant cell
Tissue Specificity Ubiquitous. Highest expression in the brain and muscle. Isoform
IIA is expressed only in the brain where it is concentrated in
axon initial segments and nodes of Ranvier. Isoform BIN1 is
widely expressed with highest expression in skeletal muscle.
Contains 1 BAR domain.
Isoform BIN1: Nucleus.
Uniprot ID Human(O00499), Mouse(O08539), Rat(O08839)
Alternative Names BIN1
May vary, we will contact you!