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Catalog # MHCP12Product Storage 4 ºCExtracellular matrix (ECM) proteins play an important role in the regulation offundamental cellular processes and are widely used as a coating or matrix for tissueculture systems to permit the development of models that closely mimic invivo conditionsMatrix Hydrogels Coated plate are manufactured using collagen product andformulated with other ECM to support and promote cell growth. Matrix Hydrogel Coatedplate is a synthetic matrix that is used to achieve optimal differentiation. MatrixHydrogels coated plate bound to 6, 12, 24 and 96 well plates targeting 9 levels ofstiffness (kPa).Soft: 0.2, 0.5, 1Mid: 2, 4, 8Stiff: 12, 25, 50
The product regulated stiffness replicates a broad range of physiological tissuesoftness, from fat to cardiac muscle, so you can routinely venture beyond the rigidity oftissue culture plastic.Our Matrix Hydrogel Coated Plate help with but not limited to:Embryonic Cell:The expression of stem cells markers.Hepatocytes:Help with myofibroblastic differentiation in Hepatic stellate cells.Neural:Promote neuro branching of SH-SY5Y cell line, and other Human Neuro Cells.Heart:Help gene expression and phenotype in neonatal cardiomyocytes in vitro.Bone, Cartilage Skeletal Muscle:Increases cellular communication, and regulates skeletal muscle stem cell self-renewalin culture.General and Mechanistic:Influence of substrate stiffness on circulating progenitor cell fate. Integrin activation andinternalization on soft ECM as a mechanism of induction of stem cell differentiation byECM elasticityEye:Substrate elasticity as biomechanical modulator of tissue homeostatic parameters incorneal keratinocytes.Endothelia Cell:Endothelial barrier disruption and recovery is controlled by substrate stiffness. Thecombined influence of substrate elasticity and surface-grafted molecules on the ex vivoexpansion of hematopoietic stem and progenitor cells
Mesenchymal:Effect of matrix stiffness on the differentiation of mesenchymal stem cells in response toTGF-β.STABILITY Stable for a minimum of 3 months from date of shipment when stored at 4ºCRecommended Plating Volumes of Cell Culture Plate Growth Area (cm2) Volume PerWell (µl)Hydrogels Coated plate Growth Area (cm2) Volume Per Well (µl)6-well 9.60 120024-well 2.00 25096-well 0.32 50